منابع مشابه
Coordinating cell polarity with cell division in space and time.
Decisions of when and where to divide are crucial for cell survival and fate, and for tissue organization and homeostasis. The temporal coordination of mitotic events during cell division is essential to ensure that each daughter cell receives one copy of the genome. The spatial coordination of these events is also crucial because the cytokinetic furrow must be aligned with the axis of chromoso...
متن کاملPolarity in stem cell division: asymmetric stem cell division in tissue homeostasis.
Many adult stem cells divide asymmetrically to balance self-renewal and differentiation, thereby maintaining tissue homeostasis. Asymmetric stem cell divisions depend on asymmetric cell architecture (i.e., cell polarity) within the cell and/or the cellular environment. In particular, as residents of the tissues they sustain, stem cells are inevitably placed in the context of the tissue architec...
متن کاملMob1: defining cell polarity for proper cell division.
Mob1 is a component of both the mitotic exit network and Hippo pathway, being required for cytokinesis, control of cell proliferation and apoptosis. Cell division accuracy is crucial in maintaining cell ploidy and genomic stability and relies on the correct establishment of the cell division axis, which is under the control of the cell's environment and its intrinsic polarity. The ciliate Tetra...
متن کاملCell division orientation and planar cell polarity pathways.
The orientation of cell division has a crucial role in early embryo body plan specification, axis determination and cell fate diversity generation, as well as in the morphogenesis of tissues and organs. In many instances, cell division orientation is regulated by the planar cell polarity (PCP) pathways: the Wnt/Frizzled non-canonical pathway or the Fat/Dachsous/Four-jointed pathway. Firstly, us...
متن کاملPolarity in Cell Division What Frames Thy Fearful Asymmetry?
activity to make two daughter cells different from each San Francisco, California 94143 other, although its function in GMC is not clear. Prospero is a homeodomain-containing protein that controls cell fate by functioning as a transcriptional regulator (re-Asymmetric cell division is a basic means for generating viewed by Lu et al., 2000). cell fate diversity. In both unicellular and multicellu...
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ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80695-9